Gene information
Official symbol MME
Official full name membrane metalloendopeptidase
Gene type protein-coding gene
Chromosome3q25.2
Alias symbolCALLA; CD10; NEP
Gene familyCD molecules; M13 metallopeptidases
Resources
Entrez Gene 4311
HGNC HGNC:7154
Ensembl ENSG00000196549
Vega OTTHUMG00000158455
UCSC uc010hvr.2
GO terms: 58 records
GO Description Category LogP Number of genes Detail
GO:0001655 urogenital system development GO Biological Processes -19.5104956 58 More
GO:0001786 phosphatidylserine binding GO Molecular Functions -3.87607272 6 More
GO:0001822 kidney development GO Biological Processes -16.2664835 49 More
GO:0001890 placenta development GO Biological Processes -8.66149584 25 More
GO:0004175 endopeptidase activity GO Molecular Functions -25.2809598 44 More
GO:0005543 phospholipid binding GO Molecular Functions -6.61792344 45 More
GO:0005903 brush border GO Cellular Components -3.40315955 7 More
GO:0005925 focal adhesion GO Cellular Components -8.40302345 46 More
GO:0007568 aging GO Biological Processes -23.5429582 29 More
GO:0007610 behavior GO Biological Processes -18.1916656 76 More
GO:0007611 learning or memory GO Biological Processes -7.55755517 33 More
GO:0008233 peptidase activity GO Molecular Functions -21.0463733 46 More
GO:0008237 metallopeptidase activity GO Molecular Functions -10.3008607 18 More
GO:0008238 exopeptidase activity GO Molecular Functions -3.53660715 7 More
GO:0008289 lipid binding GO Molecular Functions -15.8223476 88 More
GO:0009314 response to radiation GO Biological Processes -9.77450393 26 More
GO:0009411 response to UV GO Biological Processes -7.07745319 13 More
GO:0009416 response to light stimulus GO Biological Processes -4.81054429 15 More
GO:0010720 positive regulation of cell development GO Biological Processes -17.713649 52 More
GO:0016485 protein processing GO Biological Processes -23.0561441 30 More
GO:0019233 sensory perception of pain GO Biological Processes -10.7642352 20 More
GO:0030055 cell-substrate junction GO Cellular Components -9.04790297 48 More
GO:0030323 respiratory tube development GO Biological Processes -8.11012280 27 More
GO:0030324 lung development GO Biological Processes -8.32855168 27 More
GO:0030424 axon GO Cellular Components -6.14132550 54 More
GO:0030425 dendrite GO Cellular Components -4.55233052 48 More
GO:0030667 secretory granule membrane GO Cellular Components -8.32957622 38 More
GO:0033218 amide binding GO Molecular Functions -9.50305686 47 More
GO:0042803 protein homodimerization activity GO Molecular Functions -14.2815375 77 More
GO:0043025 neuronal cell body GO Cellular Components -9.18558636 52 More
GO:0044297 cell body GO Cellular Components -11.7206640 62 More
GO:0044306 neuron projection terminus GO Cellular Components -2.47884900 13 More
GO:0045121 membrane raft GO Cellular Components -30.0775030 71 More
GO:0048167 regulation of synaptic plasticity GO Biological Processes -4.27696718 22 More
GO:0048608 reproductive structure development GO Biological Processes -16.4007448 61 More
GO:0050435 amyloid-beta metabolic process GO Biological Processes -2.73474492 3 More
GO:0050767 regulation of neurogenesis GO Biological Processes -15.7439029 55 More
GO:0050769 positive regulation of neurogenesis GO Biological Processes -12.1167088 37 More
GO:0050804 modulation of chemical synaptic transmission GO Biological Processes -15.2260557 60 More
GO:0050806 positive regulation of synaptic transmission GO Biological Processes -4.32260958 18 More
GO:0050890 cognition GO Biological Processes -8.00500082 37 More
GO:0051604 protein maturation GO Biological Processes -20.0856790 31 More
GO:0051960 regulation of nervous system development GO Biological Processes -17.2202851 64 More
GO:0051962 positive regulation of nervous system development GO Biological Processes -13.2580156 43 More
GO:0060284 regulation of cell development GO Biological Processes -22.9455891 78 More
GO:0060541 respiratory system development GO Biological Processes -8.30305934 29 More
GO:0061458 reproductive system development GO Biological Processes -16.2516665 61 More
GO:0071345 cellular response to cytokine stimulus GO Biological Processes -39.647808 70 More
GO:0072001 renal system development GO Biological Processes -17.7796243 52 More
GO:0072341 modified amino acid binding GO Molecular Functions -2.85016161 6 More
GO:0097447 dendritic tree GO Cellular Components -4.82959150 49 More
GO:0098793 presynapse GO Cellular Components -4.56552653 42 More
GO:0098857 membrane microdomain GO Cellular Components -30.8181788 72 More
GO:0098862 cluster of actin-based cell projections GO Cellular Components -2.30896381 7 More
GO:0099177 regulation of trans-synaptic signaling GO Biological Processes -15.1793607 60 More
GO:0140448 signaling receptor ligand precursor processing GO Biological Processes -9.03552172 9 More
GO:1900271 regulation of long-term synaptic potentiation GO Biological Processes -4.53716649 6 More
GO:1900273 positive regulation of long-term synaptic potentiation GO Biological Processes -2.48965564 3 More
KEGG pathways: 2 records
KEGG Description Category LogP Number of genes Detail
hsa04640 Hematopoietic cell lineage KEGG Pathway -11.4657972 15 More
hsa04974 Protein digestion and absorption KEGG Pathway -4.19153592 8 More
Drug-Gene interaction
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Related drugs: 8 records
Related studies: 2 records
Molecular factor Omics type Application Objective MI type Reference
neprilysin proteomics morphine[treatment (pharmacotherapy)] acute ST elevation myocardial infarction Wang TL et al. Ann Emerg Med. 2001
neprilysin proteomics left ventricular ejection fraction[other] acute ST elevation myocardial infarction Legallois D et al. BMC Cardiovasc Disord. 2020
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